ONTOLOGY SOURCE REFERENCE
Term Source Name	"ArrayExpress"	"EFO"	"CHEBI"	"NCBITaxon"	"BTO"	"GO"	
Term Source File	"http://www.ebi.ac.uk/arrayexpress/"	"http://www.ebi.ac.uk/efo/efo.owl"	"http://bioportal.bioontology.org/ontologies/50447"	"http://bioportal.bioontology.org/ontologies/47845"	"http://bioportal.bioontology.org/ontologies/50231"	"http://bioportal.bioontology.org/ontologies/50465"	
Term Source Version	""	""	"50447"	"47845"	"50231"	"50465"	
Term Source Description	""	""	"Chemical Entities of Biological Interest Ontology"	"National Center for Biotechnology Information (NCBI) Organismal Classification"	"BRENDA Tissue and Enzyme Source Ontology"	"Gene Ontology"	
INVESTIGATION
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INVESTIGATION PUBLICATIONS
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INVESTIGATION CONTACTS
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STUDY
Study Identifier	"E-GEOD-32226"
Study Title	"Expression profiling of peripheral blood cells from patients with coronary artery disease. All patients were treated chronically with aspirin and the antiplatelet drug clopidogrel (Plavix). [original title: Expression data for pharmacogenomics antiplatelet therapy]"
Study Description	"26 male patients were taking 100 mg/day aspirin and 75 mg/day clopidogrel. Patients were classified as responder, partial responder, or non-responder to each drug, and they were scored for age (range: 38-79), BMI, ARU, and PRU. [original description, slightly edited: Antiplatelet therapy is the most important treatment to reduce the risk of developing recurrent thrombosis and to prevent progression to a complete occlusion of coronary arterial disease (CAD) patients after percutaneous coronary intervention. The aim of this study was to investigate the relationship between response to antiplatelet drugs and global mRNA gene expression in peripheral blood cells (PBC) in patients with coronary arterial disease (CAD). All patients were treated chronically with acetylsalicylic acid (ASA, aspirin; 100 mg/day) and clopidogrel (cf. Plavix; 75 mg/day). Blood samples were drawn before percutaneous coronary intervention (PCI) to evaluate platelet reactivity by VerifyNow¨ ASA and P2Y12 assays, and mRNA expression was measured by Affymetrix GeneChip Human Exon 1.0 ST array.]"
Comment[Study Grant Number]	""
Comment[Study Funding Agency]	""
Study Submission Date	""
Study Public Release Date	"2012-09-15"
Study File Name	"s_E-GEOD-32226_study_samples.txt"
STUDY DESIGN DESCRIPTORS
Study Design Type	"transcription profiling by array"
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STUDY PUBLICATIONS
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STUDY FACTORS
Study Factor Name	"bmi"	"aru value"	"response"	"age"	"pru value"	"NSAID"	"other drug"	"NSAID response"	"other drug response"
Study Factor Type	"bmi"	"aru value"	"response"	"age"	"pru value"	"chemical compound"	"chemical compound"	"response to drug"	"response to drug"
Study Factor Type Term Accession Number	""	""	""	""	""	""	""	"GO:0042493"	"GO:0042493"
Study Factor Type Term Source REF	""	""	""	""	""	""	""	"GO"	"GO"
STUDY ASSAYS
Study Assay File Name	"a_E-GEOD-32226_GeneChip_assay.txt"
Study Assay Measurement Type	"transcription profiling"
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Study Assay Technology Type	"DNA microarray"
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STUDY PROTOCOLS
Study Protocol Name	"P-GSE32226-1"	"P-GSE32226-6"	"P-GSE32226-5"	"P-GSE32226-2"	"P-GSE32226-3"	"P-GSE32226-4"	"P-GSE32226-7"
Study Protocol Type	"bioassay_data_transformation"	"image_aquisition"	"hybridization"	"specified_biomaterial_action"	"nucleic_acid_extraction"	"labeling"	"feature_extraction"
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Study Protocol Description	"ID_REF =  VALUE = RMA signal estimates from Expression Console Software version 1.1"	"GeneChips were scanned using the a GeneArray Scanner (Affymetrix)."	"Following fragmentation, 10 ug of cRNA were hybridized for 16 hr at 45C on GeneChip Human Exon 1.0 ST Array. GeneChips were washed and stained in the Affymetrix Fluidics Station."	"All patients were treated chronically with acetylsalicylic acid (ASA) (100 mg/day) and clopidogrel (75 mg/day)."	"Total RNA extraction was performed using the commercially available kit PAXgene Blood RNA, and samples were automatically prepared using spin-column kits Qiacube."	"Biotinylated cRNA were prepared according to the standard Affymetrix protocol."	"Raw data were processed with the Expression Console (Affymetrix) with gene leval and for background correction and normalization. For the microarray data statystic analisis was performed using Partek¨ Genomic Suite (Partek Inc, St. Louis, USA).  We defined a probeset as present when it had a P value <0.01 ."
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STUDY CONTACTS
Study Person Last Name	"Luchessi"	"Luchessi"	"Silbiger"	"Hirata"	"Lima-Neto"	"Cavichioli"	"Iñiguez"	"Bravo"	"Bastos"	"Sousa"	"Brión"	"Carracedo"	"Hirata"
Study Person First Name	"Andre"	"André"	"Vivian"	"Rosario"	"Lidio"	"Debora"	"Andres"	"Marisol"	"Guillermo"	"Amanda"	"Maria"	"Angel"	"Mario"
Study Person Mid Initials	"Ducati"	"D"	"N"	"D"	"G"	""	""	"S"	""	"G"	""	""	"H"
Study Person Email	"adluchessi@usp.br"	""	""	""	""	""	""	""	""	""	""	""	""
Study Person Phone	"551130913660"	""	""	""	""	""	""	""	""	""	""	""	""
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Study Person Address	"University of Sao Paulo, Av. Prof Lineu Prestes, 580, Sao Paulo, Brazil"	""	""	""	""	""	""	""	""	""	""	""	""
Study Person Affiliation	"University of Sao Paulo"	""	""	""	""	""	""	""	""	""	""	""	""
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